Genetically engineered mice in drug development
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چکیده
منابع مشابه
Genetically Engineered Mice Predicting Drug Responsiveness in Human Cancers Using
Purpose: To use genetically engineered mouse models (GEMM) and orthotopic syngeneic murine transplants (OST) to develop gene expression-based predictors of response to anticancer drugs in human tumors. These mouse models offer advantages including precise genetics and an intact microenvironment/
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PURPOSE To use genetically engineered mouse models (GEMM) and orthotopic syngeneic murine transplants (OST) to develop gene expression-based predictors of response to anticancer drugs in human tumors. These mouse models offer advantages including precise genetics and an intact microenvironment/immune system. EXPERIMENTAL DESIGN We examined the efficacy of 4 chemotherapeutic or targeted antica...
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Drug development and preclinical trials are challenging processes and more than 80% to 90% of drug candidates fail to gain approval from the United States Food and Drug Administration. Predictive and efficient tools are required to discover high quality targets and increase the probability of success in the process of new drug development. One such solution to the challenges faced in the develo...
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There is evidence that genetic factors play a role in the complex multifactorial pathogenesis of hydrocephalus. Identification of the genes involved in the development of this neurologic disorder in animal models may elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans. The authors report here a brief summary of findings from 12 lines of ge...
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ژورنال
عنوان ژورنال: Journal of Internal Medicine
سال: 1999
ISSN: 0954-6820,1365-2796
DOI: 10.1046/j.1365-2796.1999.00491.x